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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DYRK3
All Species:
45.76
Human Site:
Y209
Identified Species:
71.9
UniProt:
O43781
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.14
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O43781
NP_001004023.1
588
65714
Y209
R
D
H
L
A
Y
R
Y
E
V
L
K
I
I
G
Chimpanzee
Pan troglodytes
XP_524527
588
65774
Y209
R
D
H
L
A
Y
R
Y
E
V
L
K
I
I
G
Rhesus Macaque
Macaca mulatta
XP_001086117
588
65769
Y209
R
D
H
L
A
Y
R
Y
E
V
L
K
I
I
G
Dog
Lupus familis
XP_537131
637
71340
Y259
R
D
H
L
A
Y
R
Y
E
V
L
K
I
I
G
Cat
Felis silvestris
Mouse
Mus musculus
Q922Y0
586
65553
Y208
R
D
H
L
A
Y
R
Y
E
V
L
K
I
I
G
Rat
Rattus norvegicus
Q4V8A3
586
65492
Y208
R
D
H
L
A
Y
R
Y
E
V
L
K
I
I
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511087
546
60615
A185
S
F
G
Q
V
V
K
A
F
D
H
K
A
Q
H
Chicken
Gallus gallus
Q5ZIU3
526
59419
R186
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
Frog
Xenopus laevis
NP_001088793
567
63329
Y189
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
Zebra Danio
Brachydanio rerio
NP_001108400
581
65351
Y200
H
D
H
L
A
Y
R
Y
E
F
L
K
V
I
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P83102
828
92722
Y276
H
D
H
V
A
Y
R
Y
E
M
L
K
I
I
G
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
NP_001023207
817
89866
Y461
H
D
H
I
A
Y
R
Y
E
V
L
K
V
I
G
Sea Urchin
Strong. purpuratus
XP_799140
561
63192
Y193
H
D
H
V
A
Y
R
Y
E
V
L
K
I
L
G
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P51566
467
54180
K138
E
C
F
D
N
K
N
K
E
V
V
A
I
K
V
Baker's Yeast
Sacchar. cerevisiae
P14680
807
91227
Y369
G
V
E
Q
N
R
K
Y
L
V
L
D
I
L
G
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
98.8
85.7
N.A.
89.6
90.8
N.A.
57.9
59
65.3
63.4
N.A.
39
N.A.
40.5
54.7
Protein Similarity:
100
99.4
99.4
88.8
N.A.
93.5
94.2
N.A.
70.7
71.9
77.8
76.6
N.A.
50.9
N.A.
52.5
68.3
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
6.6
13.3
80
80
N.A.
80
N.A.
80
80
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
13.3
40
93.3
86.6
N.A.
93.3
N.A.
93.3
93.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
22.2
26.5
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
37.7
41
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
20
33.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
26.6
46.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
74
0
0
7
0
7
7
7
7
0
0
% A
% Cys:
0
7
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
74
0
7
0
0
0
0
0
7
0
7
0
0
0
% D
% Glu:
7
0
14
0
0
0
0
0
80
0
0
7
7
0
0
% E
% Phe:
0
7
7
0
0
7
0
0
7
7
0
0
0
0
0
% F
% Gly:
7
0
7
0
0
0
0
0
0
0
0
0
0
0
80
% G
% His:
34
0
74
0
0
0
7
0
0
0
7
0
0
0
7
% H
% Ile:
0
0
0
7
0
0
0
0
0
0
0
0
67
74
0
% I
% Lys:
0
0
0
7
0
7
14
7
0
0
0
80
0
7
0
% K
% Leu:
0
0
0
47
0
0
0
0
7
0
80
0
0
14
0
% L
% Met:
0
0
0
0
0
0
0
0
0
7
0
0
0
0
0
% M
% Asn:
0
7
0
0
14
0
7
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
14
0
0
0
0
7
0
0
0
0
7
0
% Q
% Arg:
47
0
0
0
7
7
74
7
0
0
0
0
0
0
7
% R
% Ser:
7
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
7
0
20
7
7
0
0
0
74
7
0
20
0
7
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
74
0
80
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _